Clearly this term has exploded in popularity as everybody moved to using many of the newer sequencing technologies as opposed to the traditional Sanger method.
So clearly, some topics are becoming more popular, and more searched for. However I still feel that the decline for the term bioinformatics might indeed represent a real decline in the whole field of bioinformatics. That is not to say that I think less bioinformatics is being done these days, or that it is less 'worthy' as a field. Rather, I think bioinformatics has moved from being a specialist field that was carried out somewhat separately from 'traditional' wet-lab research, to something which is much more integrated with many other fields of research. There are still many dedicated bioinformatics group (the lab where I work is one such group), but I think that it is increasingly common that biologists need to — and want to — undertake some bioinformatics as part of their wider research. To me, bioinformatics has become part of mainstream biological research and that means that it no longer makes sense to think of it as a separate field as such.
Anyway, regardless of whether any particular biological term is rising or falling in popularity, I think it is more interesting to see what search terms remain eternally popular. Despite changing governments, economic turmoil, and global uncertainty what is it that we search for with any degree of constancy? My first guess seemed to be a good one. So let me end by presenting the Google Insights graph for the search term shoes:
